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Document 2786
DOCN M94A2786
TI CD4 counts during treatment of herpes simplex infection in HIV-1
infected children.
DT 9412
AU Fomin J; Voronin E; Rakhmanova A; Popova I; Medical Academy Postgraduate
Education, St. Petersburg, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):225 (abstract no. PB0328). Unique
Identifier : AIDSLINE ICA10/94369789
AB OBJECTIVE: Herpes simplex virus 1 (HSV 1) infection of skin is the most
often clinical symptom in russian children infected HIV-1 by parenteral
route. The aim was to examine changes in CD4 counts in the course of HSV
1 infection in children long-term treated by Retrovir (Wellcome). We
also wished to compare CD4 counts in patients with Retrovir+Zovirax
(Wellcome) therapy. METHODS: From 1/1991 to 12/1992 55 children aged 4-7
year-old with parenteral HIV-1 infection (all class P 2) were included
in the analysis. All the patients have had clinical manifestations of
HSV 1 infection as a recurrent vesicular lesions of cutaneous surfaces
and were long-treated by oral Retrovir in 1-year period. HSV 1 was
detected using DNA hybridization assay. At the same time, the sera were
tested using ELISA methods for IgM and IgG antibodies to HSV 1. CD4
cells were studied in children using monoclonal antibodies, flow
cytometry and immunofluorescence test. The obtained variables were
examined statistically (Student's criterium). RESULTS: All patients were
divided in two groups. In G1 were 20 patients treated with Zovirax in
dosage 1000 mg/d orally during 2 weeks. Average CD4 counts in this group
before (18.5%-372/mm3) and after treatment (21.1%-505/mm3) were
statistically different. In G2 group were 35 children not treated by
Zovirax, those CD4 counts were examined before recurrence of HSV 1
infection (21.6%-549/mm3) and after the clearing of skin
(18.5%-372/mm3). In this group were registered progressive decline CD4
cells after episode of HSV 1 infection. CONCLUSION: 1) Recurrent
cutaneous HSV 1 infection in parenterally HIV-1 infected children
4-7-year-old followed by declining CD4 cells despite of long-term
antiretroviral therapy by Retrovir. 2) Treatment by Retrovir+Zovirax
appeared to be more effective to increase initial CD4 count.
DE Acyclovir/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Child Child,
Preschool Comparative Study Drug Therapy, Combination Herpes
Simplex/*BLOOD/DRUG THERAPY/IMMUNOLOGY Human HIV
Infections/*COMPLICATIONS HIV-1 *Leukocyte Count/DRUG EFFECTS *T4
Lymphocytes Zidovudine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).